Glutathione S-transferase polymorphism and prostate cancer
نویسندگان
چکیده
منابع مشابه
Prostate cancer and glutathione S-transferase deletions
GSTM1 and GSTT1 gene polymorphisms have been studied in many populations to evaluate their association with prostate cancer risk with contrasting results. The current study was aimed to find out the association of GSTM1 and GSTT1 gene polymorphisms with prostate cancer in Pakistani men. This case control study included pathologically confirmed prostate cancer patients and age matched male contr...
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Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype frequency in prostate cancer cases i...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2009
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2009.112